Carvedilol suppresses arrythmiogenicity in essential hypertensives

Carvedilol suppresses intractable hiccups.

Carvedilol (6.25 mg, 4 times daily) relieved 2 years of constant hiccupping, marked tardive dyskinesia, compulsive self-induced vomiting, and feelings of hopelessness and low mood in a 59-year-old African-American man. He previously failed trials of ranitidine, chlorpromazine, promethazine, tegaserod, ondansetron, metoclopramide, pantoprazole, pyloric injections of botulinum toxin A, and a vaga...

Alterations in aldosterone biosynthesis in essential hypertensives.

We studied hypertensives with decreased adrenal responsiveness to infused angiotensin II (AII) to assess their responsiveness to other aldosterone secretagogues, ACTH and potassium, which are thought to stimulate aldosterone synthesis in sites different from one another and from AII. All subjects, following sodium restriction, received an infusion of AII in increasing doses (0.1-3 ng/kg per min...

Association analyses of S(A) gene variant in essential hypertensives.

A gene designated S(A) has been implicated in hypertension (HT) in rat genetic models and Japanese HT patients. However, a linkage study in whites was negative. Because of the limitations of genetic analyses, confirmation in different settings is imperative. Therefore, we conducted a cross-sectional case-control study involving 106 HT and 96 normotensive (NT) white subjects. A polymerase chain ...

Association of QT Dispersion with Left Ventricular Hypertrophy in Essential Hypertensives

Circadian Variation of Blood Pressure is Correlated to Vascular Endothelial Function in Nondiabetic Essential Hypertensives

Background: Hypertension is associated with altered endothelial nitric oxide (NO) release. Abnormal endotheliumdependent vascular relaxation in patients with primary hypertension has been described and is associated with abnormalities of the NO system. Little is known about the relationship between the circadian rhythm of blood pressure (BP) and endothelial function in patients with essential h...